Experimental research is directed to : provide data for numerical simulations by investigation of mechanical characteristics and functional properties of various tissue such as blood vessels and visceral organs walls investigate effects of biological active molecules on the isolated blood vessels, isolated heart and other contractile tissues transport studies of biologic active molecules at physiological membranes ( in the isolated heart, blood vessels, chorioid plexus, hematoencefalic barrier, colon epithelium in using chamber etc.) development of experimental methods and laboratory equipment design (artificial heart device, stretch system for biomechanical and functional tissue investigation)
Biomechanical and functional properties of various arterial and vein blood vessels include: experimental atherosclerosis and experimental models of hypertension as well as vein and artificial graft estimation. Search for better remodeling, as well as estimation of optimal functional and biomechanical properties of vein graft is necessary in order to improve long term outcome after vascular surgical interventions Defining of transport characteristics (mechanisms, kinetics and dynamic of molecules transport) under physiological conditions will allow forming of data base that can be useful as a basic point in pharmacology, pharmacy, dietetic technology, physiology and wide spectrum of clinical disciplines. Changes of various molecule transport characteristics under pathological conditions can be of direct applicative importance due to improvement of therapeutic approach efficiency at the level of clinical practice. Improving of experimental methods and laboratory equipment allows development of original software and hardware for rapid communication between laboratory equipment and PC with capability of automatic mathematical analysis of registered parameters with computational processing of final results. |
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Erfahrungsbericht:Rumänien
