| Our team works on formalized description, visualization, and analysis of complex biological systems. It is currently developing the BioUML workbench>>, a free, open source, extensible software framework for systems biology, which, in turn, is being used as a tool for the development of the Cyclonet database - a database for cell cycle regulation in eukaryotes >> Fedor Kolpakov, previously also developed and co-developed: MGL - Molecular Genetics Language - for search, extraction from databases, sample generation, visualization, and analysis of regulatory genomic sequences (Kolpakov, Babenko, 1997); GeneNet (Kolpakov et. al,1998; Kolpakov, Ananko, 1999) for formalized description and visualization of gene networks; TRRD viewer - Java applet for visualization of TRRD database content (Heinmeyer et al., 1998). He also participated in the development of FunSite which was designed for the analyses of gene regulatory regions and results visualization (Kel et al., 1995), GeneExpress that is an integrator for databases and computer systems accessible by the Internet and intended for studying eukaryotic gene expression (Kolchanov et al., 1998). In collaboration with BIOBASE, Fedor was recently involved with the development of TRANSPLORER>, a system for the analysis of gene regulatory regions. Our team is involved in formalized description, visualization, simulation and analysis of mammalian cell-cycle regulatory networks in normal and pathological states using our BioUML tool. Our modeling team brings a lot of expertise in system biology methods to model complex biological systems. The BioUML workbench has been provided to the consortia as a common platform to collect data, and to construct the cell cycle model. 
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Erfahrungsbericht:Rumänien
Framework for Systems Biology
